Contents | Science Signaling 15, 716

ONLINE COVER This week, Kim et al. report that zinc metabolically reprograms monocytes and macrophages to promote inflammation in rheumatoid arthritis. The image is an illustration of a coronal section through a rheumatoid arthritis–afflicted knee joint.

Credit: John Bavosi/Science Source

Science Signaling

Volume 15|
Issue 716|
11 Jan 2022

Credit: John Bavosi/Science Source

Research Articles

Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis

- Bonah Kim
- Hee Young Kim
- Bo Ruem Yoon
- Jina Yeo
- Ji In Jung
- Kyung-Sang Yu
- Hyeon Chang Kim
- Su-Jin Yoo
- Jin Kyun Park
- Seong Wook Kang
- Won-Woo Lee
11 Jan 2022
NO ACCESS

Zinc metabolically reprograms monocytes and macrophages to promote inflammation in rheumatoid arthritis.

Abstract

The essential micronutrient zinc regulates immune responses by affecting signaling pathways. In activated monocytes and macrophages, signaling networks mediate the metabolic reprogramming that meets the demands of participation in immune responses. Here, ...

Redox-dependent internalization of the purinergic P2Y₆ receptor limits colitis progression

- Kazuhiro Nishiyama
- Akiyuki Nishimura
- Kakeru Shimoda
- Tomohiro Tanaka
- Yuri Kato
- Takahiro Shibata
- Hiroshi Tanaka
- Hitoshi Kurose
- Yasu-Taka Azuma
- Hideshi Ihara
- Yoshito Kumagai
- Takaaki Akaike
- Philip Eaton
- Koji Uchida
- Motohiro Nishida
11 Jan 2022
NO ACCESS

Cysteine modification of the purinergic receptor P2Y₆R promotes internalization and degradation and limits colitis progression.

Abstract

After ligand stimulation, many G protein–coupled receptors (GPCRs) undergo β-arrestin–dependent desensitization, during which they are internalized and either degraded or recycled to the plasma membrane. Some GPCRs are not subject to this type of ...