Contents | Science Immunology 7, 67

ONLINE COVER Trail Markers for Tissue Macrophages. This month's cover illustration depicts a trail marker post in a desert landscape that provides a guide to deciphering the diversity among mouse and human tissue-resident macrophages. The trio of phenotypes (TLF⁺, CCR2⁺ and MHC-II⁺) listed on the post represent three conserved macrophage subsets defined by Dick et al. These subsets share common core gene signatures and life cycles across 17 different mouse tissues.

Credit: Ella Maru Studio

Science Immunology

Volume 7|
Issue 67|
7 Jan 2022

Credit: Ella Maru Studio

Focus

Not just “leuko” after all: Epithelial leukotriene production in type 2 immunity

- Fiona D. R. Henkel
- Julia Esser-von Bieren
07 Jan 2022
NO ACCESS

Epithelial tuft cells are major producers of lipid mediators (leukotrienes) that drive allergic inflammation and host defense against worm parasites. (see the related Research Article by Ualiyeva et al.).

Abstract

New research shows that specialized epithelial cells (tuft cells) are major producers of lipid mediators (leukotrienes) that drive allergic inflammation and host defense against helminth parasites. (See the related Research Article by Ualiyeva et al.)

Reviews

Innate immunological pathways in COVID-19 pathogenesis

- Søren R. Paludan
- Trine H. Mogensen
07 Jan 2022
Free

Abstract

Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound dysregulation of the innate immune system. This knowledge has emerged from the large body of single-cell omics studies of patients with COVID-19, which have provided one of the ...

Research Articles

Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles

- Sarah A. Dick
- Anthony Wong
- Homaira Hamidzada
- Sara Nejat
- Robert Nechanitzky
- Shabana Vohra
- Brigitte Mueller
- Rysa Zaman
- Crystal Kantores
- Laura Aronoff
- Abdul Momen
- Duygu Nechanitzky
- Wanda Y. Li
- Parameswaran Ramachandran
- Sarah Q. Crome
- Burkhard Becher
- Myron I. Cybulsky
- Filio Billia
- Shaf Keshavjee
- Seema Mital
- Clint S. Robbins
- Tak W. Mak
- Slava Epelman
07 Jan 2022
Free

High-dimensional analysis reveals three macrophage subsets with common transcriptional and biological properties across organs.

Abstract

Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is appreciated that different tissues instruct specialized macrophage functions. However, individual tissues contain heterogeneous subpopulations, and how these ...

A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors

- Diyuan Xue
- Benjamin Moon
- Jing Liao
- Jingya Guo
- Zhuangzhi Zou
- Yanfei Han
- Shuaishuai Cao
- Yang Wang
- Yang-Xin Fu
- Hua Peng
07 Jan 2022
NO ACCESS

A tumor-specific pro-IL-12 rejuvenated preexisting TILs to induce tumor growth delay without inducing systemic toxicity.

Abstract

It is a challenge to effectively reactivate preexisting tumor-infiltrating lymphocytes (TILs) without causing severe toxicity. Interleukin-12 (IL-12) can potently activate lymphocytes, but its clinical use is limited by its short half-life and dose-...

Research Resource

A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity

- Yannick O. Alexandre
- Dominik Schienstock
- Hyun Jae Lee
- Luke C. Gandolfo
- Cameron G. Williams
- Sapna Devi
- Bhupinder Pal
- Joanna R. Groom
- Wang Cao
- Susan N. Christo
- Claire L. Gordon
- Graham Starkey
- Rohit D’Costa
- Laura K. Mackay
- Ashraful Haque
- Burkhard Ludewig
- Gabrielle T. Belz
- Scott N. Mueller
07 Jan 2022
NO ACCESS

A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity.

Abstract

The spleen is a compartmentalized organ that serves as a blood filter and safeguard of systemic immune surveillance. Labyrinthine networks of fibroblastic stromal cells construct complex niches within the white pulp and red pulp that are important for ...