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ONLINE COVER Platelets Step Up Cancer Targets. Shown is an artistic representation of the cellular environment with two T cells (blue) attacking a tumor (pink) in the presence of platelets (gold). Rachidi et al. report that platelets constrain T cell immunity through a GARP-TGFβ axis and suggest a combination of immunotherapy and platelet inhibitors as a therapeutic strategy against cancer. [CREDIT: EMMA VOUGHT/MEDICAL UNIVERSITY OF SOUTH CAROLINA]

Science Immunology

  • Volume 2|
  • Issue 11|
  • May 2017

ONLINE COVER Platelets Step Up Cancer Targets. Shown is an artistic representation of the cellular environment with two T cells (blue) attacking a tumor (pink) in the presence of platelets (gold). Rachidi et al. report that platelets constrain T cell immunity through a GARP-TGFβ axis and suggest a combination of immunotherapy and platelet inhibitors as a therapeutic strategy against cancer. [CREDIT: EMMA VOUGHT/MEDICAL UNIVERSITY OF SOUTH CAROLINA]

Focus

    BY
    • Lucy S. K. Walker
  • NO ACCESS
PD-1–centered therapies rely on CD28 activation to promote anti-tumor immunity.

Research Articles

    BY
    • Pui Y. Lee
    • David B. Sykes
    • Sarah Ameri
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    • Pierre Cunin
    • Allyn Morris
    • Astrid E. Cardona
    • David E. Root
    • David T. Scadden
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  • NO ACCESS
The mTORC1-S6K1 pathway controls terminal differentiation of myeloid progenitors through regulation of Myc.
    BY
    • Peihong Dai
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    • Jacob M. Ricca
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  • NO ACCESS
Inactivated vaccinia virus induces antitumor immunity that can overcome resistance to checkpoint inhibitors.
    BY
    • Galina Gabriely
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  • NO ACCESS
Anti-LAP antibody induces antitumor immunity by affecting both adaptive and innate immune mechanisms.
    BY
    • Christina Guzzo
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    • Chung Park
    • Damilola Phillips
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    • Anthony S. Fauci
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  • NO ACCESS
Anti–integrin α4β7 therapy might directly interfere with the ability of HIV to home to intestinal reserviors.
    BY
    • Saleh Rachidi
    • Alessandra Metelli
    • Brian Riesenberg
    • Bill X. Wu
    • Michelle H. Nelson
    • Caroline Wallace
    • Chrystal M. Paulos
    • Mark P. Rubinstein
    • Elizabeth Garrett-Mayer
    • Mirko Hennig
    • Daniel W. Bearden
    • Yi Yang
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    • Zihai Li
  • NO ACCESS
T cell immunity against cancer in mice is enhanced with platelet-specific deletion of GARP and by platelet inhibitors.
    BY
    • Guoxin Ni
    • Hiroyasu Konno
    • Glen N. Barber
  • NO ACCESS
The E3 ligase MUL1 regulates STING-dependent innate immune responses to cytosolic DNA.

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