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Science
- Volume 369|
- Issue 6509|
- 11 Sep 2020
COVER Genetic variation among individuals affects the transcriptome differently. Here, heatmaps of differential gene expression are shown within individual bodies to visualize the results obtained by the Genotype-Tissue Expression (GTEx) Project. This special issue presents research from the final phase of the project. See page
1316. Illustration: V. Altounian/
Science, in collaboration with Christian Stolte; (Data) GTEx Consortium
Special issue
Genetic Variation
Introduction to Special Issue
Unraveling tissue-specific genomics
This Week in Science
Editorial
Editors' Choice
Products & Materials
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory
materials of potential interest to researchers.
In Brief
A roundup of weekly science policy and related news.
In Depth
Even people in the overweight category face higher risk of serious disease.
A young disease modeling expert has found her voice during the pandemic.
Panel outlines most justifiable uses if safety is ensured.
NSF program struggles to bridge scientists and communities.
Mounting fears of massive U.S. undercount spur push for independent oversight, more
time to complete 2020 count.
Data from tissues around the body boost search for genetic basis of disease.
Feature
Flush with money and a hard-won respectability, alien hunters are deploying new telescopes
and tactics.
Working Life
Letters
Books et al.
Policy Forum
The Fair Priority Model offers a practical way to fulfill pledges to distribute vaccines
fairly and equitably
Perspectives
Evolved sex differences in gene expression are pervasive, but so too is sampling bias
Seismic noise levels that correlate with human activities fell when pandemic lockdown
measures were imposed
Dipolar slices explain the origin of ferroelectricity in a material now used for memory
devices
Fecal microbiota transplant and modulation of microbial species show therapeutic promise
A nonlinear polyatomic molecule, CaOCH3, has been laser-cooled to below 1 millikelvin
Tailored polymer shells drive the assembly of a desired class of nanoparticle architectures
A transmembrane pore reveals parallels with other viruses
Trailblazing HIV researcher
Reports
Seismic background noise dramatically decreased as a result of lockdown measures in
place for mitigating the spread of COVID-19.
The atomic-scale structure of hafnium oxide explains ferroelectric properties for
very thin films.
Galaxy clusters contain more small-scale gravitational lenses than expected from cosmological
simulations.
Trophic cascades and climate change are together reshaping an iconic kelp forest ecosystem
after the loss of sea otters.
Cryo-EM structures of Escherichia coli transcription-translation complexes reveal how bacterial transcription and translation
are coupled.
Cryo-EM structures of Escherichia coli transcription-translation complexes reveal how bacterial transcription and translation
are coupled.
The symmetric top molecule CaOCH3 is laser-cooled to submillikelvin temperatures.
A polymer ligand–based strategy enables assembly of nanoscale particles into configurations
reminiscent of molecules.
Water content and mass matter more than composition for the acidity of atmospheric
aerosols in ammonia-buffered regions.
Degradation by logging, fire, and fragmentation is increasing as a spatially distinct
disturbance in the Amazon landscape.
The response of Earth’s climate system to orbital forcing has been highly state dependent
over the past 66 million years.
The hepatocyte clock and food availability control gene expression and metabolism
in nonhepatocytic cells in the liver.
Viral RNA exported from the coronavirus replication organelle is likely to be mediated
by a crown-shaped molecular pore.
Research Articles
Outliers in the human transcriptome reveal the functional effects of rare genetic
variants.
Telomere length within an individual varies in a correlated manner across most tissues.
Cell type composition, estimated from bulk tissue, maps the cellular specificity of
genetic variants.
Sex differences in the human transcriptome are widespread and tissue specific, and
they contribute to complex traits.
The Genotype-Tissue Expression (GTEx) project dissects how genetic variation affects
gene expression and splicing.
