



ONLINE COVER Lava spews from the southeast crater of the Etna Volcano in Catania, Italy on Dec. 22, 2018. Through geochemical data analysis, Paonita et al. found that a longstanding build-up of magma and gas caused the volcano to be extremely overpressurized in the weeks before the eruption. Accurate assessment of the gas balance in active volcanoes will allow for instrumental hazard evaluation during future volcanic events. [CREDIT: Fabrizio Villa/Getty Images]


ONLINE COVER Critical Crossroads. This month's cover features an immunofluorescence image of a murine tumor-draining lymph node containing metastatic melanoma cells (GFP-expressing YUMM1.7 cells; cyan). Tumor cells reach the tumor-draining lymph node via afferent lymphatic vessels that intersect with the subcapsular and interfollicular sinuses (sinus-lining lymphatic endothelial cells stained with anti-LYVE-1; orange). The sinuses run around and between B cell follicles (B cells stained with anti-B220; purple). A Review by du Bois, Heim, and Lund summarizes our current understanding of the structural biology of tumor-draining lymph nodes, how they are primed to receive metastasizing tumor cells, and their unique impact on prognosis and immunotherapy.
Credit: Haley du Bois and Annie L. Chen/NYU Grossman School of Medicine

ONLINE COVER Special Issue on Human-Robot Interaction. Prosthetic systems that provide a strong sense of agency and ownership between the user and the prosthesis will improve performance and reduce the rate of device abandonment. Marasco et al. have developed a neural-machine interface for a bionic prosthetic arm that leverages the sense of touch to enhance physical ownership and provides grip kinesthesia to enhance agency. This month's cover is a photograph of the inside socket of a bionic prosthetic arm (see also Focus by Ortiz-Catalan). [CREDIT: Courtney Shell, Dylan Beckler, Zachary Thumser, and Paul Marasco/Laboratory for Bionic Integration, Cleveland Clinic]


Image: Microscopy Core Facility, VIB Gent/Science Source


ONLINE COVER Minimizing Metastases. This scanning electron micrograph shows metastatic mouse tumor cells (in green) invading the lung parenchyma and stroma, in close contact with nearby capillaries (red). Singhal et al. studied the vascular niche after surgical resection of spontaneously metastasizing primary tumors in mice. Using transcriptomics and proteomics, they identified leucine-rich alpha-2 glycoprotein 1 (LRG1), produced by endothelial cells in response to tumor-induced inflammation, as a prometastatic molecule. Treatment with LRG1-neutralizing antibodies led to decreased metastatic burden and prolonged survival in these mice, suggesting that LRG1 may be a potential target to restrict metastatic tumor growth.[CREDIT: Eye of Science]
The Open Access journal Research, published in association with CAST, publishes innovative, wide-ranging research in life sciences, physical sciences, engineering and applied science.
The Open Access journal Plant Phenomics, published in association with NAU, publishes novel research that advances plant phenotyping and connects phenomics with other research domains.
The Open Access journal BME Frontiers, published in association with SIBET-CAS, is a platform for the multidisciplinary community of biomedical engineering, publishing wide-ranging research in the field.
The Open Access journal BioDesign Research, published in association with NAU, publishes novel research in the interdisciplinary field of biosystems design.
The Open Access journal Advanced Devices & Instrumentation, published in association with BIACD, is a forum to promote breakthroughs and application advances at all levels of electronics and photonics.
The Open Access journal Cyborg and Bionic Systems, published in association with BIT, promotes the knowledge interchange and hybrid system codesign between living beings and robotic systems.
The Open Access journal Energy Material Advances, published in association with BIT, is an interdisciplinary platform for research in multiple fields from cutting-edge material to energy science.
The Open Access journal Space: Science & Technology, published in association with BIT, promotes the exploration and research of interdisciplinary sciences in the space field.
The Journal of Remote Sensing, an Open Access journal published in association with AIR-CAS, promotes the theory, science, and technology of remote sensing, as well as interdisciplinary research within earth and information science.
The Open Access journal Health Data Science, published in association with PKU, aims to advance the horizon of health data science through transdisciplinary learning, communication, and collaboration with health practitioners and policymakers.
The Open Access journal Ultrafast Science, published in association with XIOPM, publishes cutting-edge and emerging topics in ultrafast science with broad interest from scientific communities.