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Journals
Science
- Volume 375
- Issue 6576
- 7 Jan 2022
COVER Lipid nanoparticles (spheres) use antibodies against the CD5 protein (antibodies, blue; CD5, red) to specifically target T cells while inside the bloodstream and tissues. The nanoparticles deliver mRNA to T cells, reprogramming them in vivo to transiently express chimeric antigen receptors (gold) that target pathogenic cardiac fibroblasts. In vivo–engineered T cells mitigate cardiac fibrosis and improve heart function in a mouse model. See pages 23 and 91.
Illustration: C. Bickel/Science
Science Advances
- Volume 8
- Issue 1
- 07 Jan 2022
ONLINE COVER To promote and maintain neural connectivity, endosomes carry survival signals to the nuclei of nerve cells. But how do endosomes find their way over the long distances from the synapse (the space between nerve cells) to the nucleus? Using microfluidic devices and mice, Scaramuzzino et al. found that the endosomes (blue spheres), which are tethered to molecular motors walking along the microtubule network (green rods), carry a calcium-sensing molecule on their surface that provides an internal navigation system to guide them toward the nucleus (orange globe). This work may increase understanding of several neurodegenerative diseases.
Credit: Thomas McMahonScience Immunology
- Volume 7
- Issue 67
- 07 Jan 2022
ONLINE COVER Trail Markers for Tissue Macrophages. This month's cover illustration depicts a trail marker post in a desert landscape that provides a guide to deciphering the diversity among mouse and human tissue-resident macrophages. The trio of phenotypes (TLF+, CCR2+ and MHC-II+) listed on the post represent three conserved macrophage subsets defined by Dick et al. These subsets share common core gene signatures and life cycles across 17 different mouse tissues.
Credit: Ella Maru StudioScience Robotics
- Volume 6
- Issue 61
- 15 Dec 2021
ONLINE COVER Takeoff and Landings. The ability for aerial robots to take off and land on a variety of irregular surfaces will broaden the range of environments where these robots could be deployed. Influenced by how birds take off, land, and grasp, Roderick et al. have developed a bird-inspired grasping system called Stereotyped Nature-inspired Aerial Grasper (SNAG). The researchers integrated SNAG into a quadcopter to demonstrate perching on tree branches of different sizes, orientations, and surface conditions. This month's cover is a photograph of SNAG on a quadcopter perched on a branch.
Credit: William RoderickScience Signaling
- Volume 15
- Issue 716
- 11 Jan 2022
ONLINE COVER This week, Kim et al. report that zinc metabolically reprograms monocytes and macrophages to promote inflammation in rheumatoid arthritis. The image is an illustration of a coronal section through a rheumatoid arthritis–afflicted knee joint.
Credit: John Bavosi/Science SourceScience Translational Medicine
- Volume 14
- Issue 626
- 05 Jan 2022
ONLINE COVER Heating Up Tumors. This image shows co-expression (yellow) of the oncoprotein Tribbles homolog 3 (TRIB3, green) and the acetyltransferase P300 (red) in tumor tissue from a patient with colorectal cancer. Nuclei are shown in blue. Converting immune "cold" tumors that have poor T cell infiltration to highly infiltrated, immune "hot" tumors is a promising strategy to improve outcomes for colorectal cancer. Shang et al. demonstrated that TRIB3 inhibited CD8+ T cell infiltration into colorectal tumors by reducing CXCL10 production. P300-mediated acetylation stabilized TRIB3 protein, which could be reversed by treating colorectal cancer tumor-bearing mice with a P300 inhibitor. Treatment increased CD8+ T cell infiltration into tumors and sensitized them to immune checkpoint blockade, suggesting that TRIB3 may be a useful target for colorectal cancer.
Credit: Shang et al./Science Translational MedicineScience Partner Journals
The Open Access journal Research, published in association with CAST, publishes innovative, wide-ranging research in life sciences, physical sciences, engineering and applied science.
The Open Access journal Plant Phenomics, published in association with NAU, publishes novel research that advances plant phenotyping and connects phenomics with other research domains.
The Open Access journal BMEF, published in association with SIBET-CAS, is a platform for the multidisciplinary community of biomedical engineering, publishing wide-ranging research in the field.
The Open Access journal BioDesign Research, published in association with NAU, publishes novel research in the interdisciplinary field of biosystems design.
The Open Access journal Advanced Devices & Instrumentation, published in association with BIACD, is a forum to promote breakthroughs and application advances at all levels of electronics and photonics.
The Open Access journal Cyborg and Bionic Systems, published in association with BIT, promotes the knowledge interchange and hybrid system codesign between living beings and robotic systems.
The Open Access journal Energy Material Advances, published in association with BIT, is an interdisciplinary platform for research in multiple fields from cutting-edge material to energy science.
The Open Access journal Space: Science & Technology, published in association with BIT, promotes the exploration and research of interdisciplinary sciences in the space field.
The Journal of Remote Sensing, an Open Access journal published in association with AIR-CAS, promotes the theory, science, and technology of remote sensing, as well as interdisciplinary research within earth and information science.
The Open Access journal Health Data Science, published in association with PKU, aims to advance the horizon of health data science through transdisciplinary learning, communication, and collaboration with health practitioners and policymakers.
The Open Access journal Ultrafast Science, published in association with XIOPM, publishes cutting-edge and emerging topics in ultrafast science with broad interest from scientific communities.
The Open Access journal Ocean-Land-Atmosphere Research (OLAR), published in association with SML-ZHUHAI, publishes technologically innovative research in marine, terrestrial, and atmospheric studies and the interactions among them.