
Science Translational Medicine
- Volume 14
- Issue 626
- 05 Jan 2022

ONLINE COVER Heating Up Tumors. This image shows co-expression (yellow) of the oncoprotein Tribbles homolog 3 (TRIB3, green) and the acetyltransferase P300 (red) in tumor tissue from a patient with colorectal cancer. Nuclei are shown in blue. Converting immune "cold" tumors that have poor T cell infiltration to highly infiltrated, immune "hot" tumors is a promising strategy to improve outcomes for colorectal cancer. Shang et al. demonstrated that TRIB3 inhibited CD8+ T cell infiltration into colorectal tumors by reducing CXCL10 production. P300-mediated acetylation stabilized TRIB3 protein, which could be reversed by treating colorectal cancer tumor-bearing mice with a P300 inhibitor. Treatment increased CD8+ T cell infiltration into tumors and sensitized them to immune checkpoint blockade, suggesting that TRIB3 may be a useful target for colorectal cancer.
Credit: Shang et al./Science Translational Medicine- Shuang Shang
- Yu-wei Yang
- et al.
TRIB3 reduces CD8+ T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer
- Deobrat Dixit
- Briana C. Prager
- et al.
Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases
- Chae Kim
- Tracy Haldiman
- et al.
Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease
- Qiyun Huang
- Andreia C. Pereira
- et al.
GABAB receptor modulation of visual sensory processing in adults with and without autism spectrum disorder
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Science Translational Medicine is the leading weekly online journal publishing research at the intersection of science, engineering and medicine. The goal of Science Translational Medicine is to promote human health by providing a forum for communicating the latest research advances from biomedical, translational, and clinical researchers from all established and emerging disciplines relevant to medicine.
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