ONLINE COVER Minimizing Metastases. This scanning electron micrograph shows metastatic mouse tumor cells (in green) invading the lung parenchyma and stroma, in close contact with nearby capillaries (red). Singhal et al. studied the vascular niche after surgical resection of spontaneously metastasizing primary tumors in mice. Using transcriptomics and proteomics, they identified leucine-rich alpha-2 glycoprotein 1 (LRG1), produced by endothelial cells in response to tumor-induced inflammation, as a prometastatic molecule. Treatment with LRG1-neutralizing antibodies led to decreased metastatic burden and prolonged survival in these mice, suggesting that LRG1 may be a potential target to restrict metastatic tumor growth.[CREDIT: Eye of Science]