Science Signaling

Research Articles11 Jan 2022

Redox-dependent internalization of the purinergic P2Y₆ receptor limits colitis progression

Reviews2 Feb 2021

Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling

Reviews24 Mar 2020

RAS, wanted dead or alive: Advances in targeting RAS mutant cancers

Science Signaling

Volume 15
Issue 716
11 Jan 2022

ONLINE COVER This week, Kim et al. report that zinc metabolically reprograms monocytes and macrophages to promote inflammation in rheumatoid arthritis. The image is an illustration of a coronal section through a rheumatoid arthritis–afflicted knee joint.

Credit: John Bavosi/Science Source

Research ArticlesBy

Bonah Kim
Hee Young Kim
et al.

Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis

Research ArticlesBy

Kazuhiro Nishiyama
Akiyuki Nishimura
et al.

Redox-dependent internalization of the purinergic P2Y₆ receptor limits colitis progression

Editors' ChoiceBy

Annalisa M. VanHook

Retinoic acid for gut health

View table of contents

Research

11 Jan 2022

Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis

4 Jan 2022

DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway

Liu Liu
Xiaoming Dai
et al.

21 Dec 2021

Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage–induced cytokine production

Sara H. Small
E. Jessica Tang
et al.

21 Dec 2021

Specificities of Gβγ subunits for the SNARE complex before and after stimulation of α_2a-adrenergic receptors

Yun Young Yim
W. Hayes McDonald
et al.

21 Dec 2021

Suppression of caspase 8 activity by a coronin 1–PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling

Mayumi Mori
Julie Ruer-Laventie
et al.

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