
Science Immunology
- Volume 6
- Issue 63
- 03 Sep 2021

ONLINE COVER Critical Crossroads. This month's cover features an immunofluorescence image of a murine tumor-draining lymph node containing metastatic melanoma cells (GFP-expressing YUMM1.7 cells; cyan). Tumor cells reach the tumor-draining lymph node via afferent lymphatic vessels that intersect with the subcapsular and interfollicular sinuses (sinus-lining lymphatic endothelial cells stained with anti-LYVE-1; orange). The sinuses run around and between B cell follicles (B cells stained with anti-B220; purple). A Review by du Bois, Heim, and Lund summarizes our current understanding of the structural biology of tumor-draining lymph nodes, how they are primed to receive metastasizing tumor cells, and their unique impact on prognosis and immunotherapy.
Credit: Haley du Bois and Annie L. Chen/NYU Grossman School of Medicine- Haley du Bois
- Taylor A. Heim
- et al.
Tumor-draining lymph nodes: At the crossroads of metastasis and immunity
- Sheikh Abdul Rahman
- Bhrugu Yagnik
- et al.
PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8+ T cells in lymphoid tissue
Advertisement
Focus
Science Immunology publishes original, peer-reviewed, science-based research articles that report critical advances in all areas of immunological research, including important new tools and techniques.
mission & scope




























