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Science Immunology

  • Volume 7
  • Issue 69
  • Mar 2022
Go to Science Immunology
Go to Science Immunology

ONLINE COVER Tickling Tuft Cells with Photons. This month’s cover cover shows a pulse of blue light illuminating mouse gallbladder tissue mounted in an organ bath. Using tissue from transgenic mice expressing a light-sensitive channelrhodopsin protein in epithelial tuft cells, Keshavarz et al. found that activation of biliary tract tuft cells induced release of acetylcholine and cysteinyl leukotrienes, inflammatory mediators that elicited mucus secretion and smooth muscle contraction, respectively. A separate study by O’Leary et al. compared the transcriptomes of biliary and small intestinal tuft cells and identified bile acids as negative regulators of gallbladder tuft cell abundance.

Credit: Maryam Keshavarz/Justus Liebig University Giessen

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Science Immunology publishes original, peer-reviewed, science-based research articles that report critical advances in all areas of immunological research, including important new tools and techniques.

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