
Science Immunology
- Volume 7
- Issue 69
- Mar 2022

ONLINE COVER Tickling Tuft Cells with Photons. This month’s cover cover shows a pulse of blue light illuminating mouse gallbladder tissue mounted in an organ bath. Using tissue from transgenic mice expressing a light-sensitive channelrhodopsin protein in epithelial tuft cells, Keshavarz et al. found that activation of biliary tract tuft cells induced release of acetylcholine and cysteinyl leukotrienes, inflammatory mediators that elicited mucus secretion and smooth muscle contraction, respectively. A separate study by O’Leary et al. compared the transcriptomes of biliary and small intestinal tuft cells and identified bile acids as negative regulators of gallbladder tuft cell abundance.
Credit: Maryam Keshavarz/Justus Liebig University Giessen- Ruihan Tang
- Nandini Acharya
- et al.
Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function
- Ziqi Long
- Bethan Phillips
- et al.
Competition for refueling rather than cyclic reentry initiation evident in germinal centers
- Emilie J. Cosway
- Andrea J. White
- et al.
Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration
- Maryam Keshavarz
- Schayan Faraj Tabrizi
- et al.
Cysteinyl leukotrienes and acetylcholine are biliary tuft cell cotransmitters
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Science Immunology publishes original, peer-reviewed, science-based research articles that report critical advances in all areas of immunological research, including important new tools and techniques.
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