
Science
- Volume 375
- Issue 6576
- 7 Jan 2022

COVER Lipid nanoparticles (spheres) use antibodies against the CD5 protein (antibodies, blue; CD5, red) to specifically target T cells while inside the bloodstream and tissues. The nanoparticles deliver mRNA to T cells, reprogramming them in vivo to transiently express chimeric antigen receptors (gold) that target pathogenic cardiac fibroblasts. In vivo–engineered T cells mitigate cardiac fibrosis and improve heart function in a mouse model. See pages 23 and 91.
Illustration: C. Bickel/Science
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- M. Nikolaev
- et al.
Tissue geometry drives deterministic organoid patterning
- Nikola Maksimovic
- Daniel H. Eilbott
- et al.
Evidence for a delocalization quantum phase transition without symmetry breaking in CeCoIn5
- Beate Kraft
- Nico Jehmlich
- et al.
Oxygen and nitrogen production by an ammonia-oxidizing archaeon
- Ton N. Schumacher
- Daniela S. Thommen
- et al.
Tertiary lymphoid structures in cancer
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