

Science Advances
- Volume 7
- Issue 52
- 24 Dec 2021

ONLINE COVER Endoggresomes, which are toxic to nerve cells, form within nerve fibers. These swellings are common features of neurodegenerative diseases, including rare, inherited forms of prion diseases—disorders that cause rapidly developing dementia, severe disability, and death. Chassefeyre et al. identified the toxic pathway of endoggresomes as it forms along microtubules and moves into the axon. The research could lead to targeted therapeutic strategies to reduce the formation of toxic endoggresomes and, in turn, to prevent neuronal dysfunction.
Robert Heller. Heller, Inc.- Michael Gerckens
- Kenji Schorpp
- et al.
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics
- Romain Chassefeyre
- Tai Chaiamarit
- et al.
Endosomal sorting drives the formation of axonal prion protein endoggresomes
- Francesco Caravelli
- Forrest C. Sheldon
- et al.
Global minimization via classical tunneling assisted by collective force field formation
- Guangxi Wang
- Hantao Yao
- et al.
Metabolic detection and systems analyses of pancreatic ductal adenocarcinoma through machine learning, lipidomics, and multi-omics
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Science Advances is the American Association for the Advancement of Science’s (AAAS) open access multidisciplinary journal, publishing impactful research papers and reviews in any area of science, in both disciplinary-specific and broad, interdisciplinary areas.
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