ONLINE COVER A pregnant person checks the pocket watch that tracks the chronicity of their pregnancy while many factors that impact pregnancy progression surround them. Preterm birth is the single largest cause of death in children under 5. While many factors are associated with preterm birth, the biological mechanisms of the disease remain unknown. Espinosa et al. use a machine learning approach to reveal insights into the interplay between biological, phenotypical, and environmental factors contributing to premature and healthy pregnancies. This conceptual contribution paves the way to a comprehensive understanding of pregnancy and therapeutic interventions for its complications.