Vascular diseases await translation of blood vessels engineered from stem cells
Science Translational Medicine • 14 Oct 2015 • Vol 7, Issue 309 • p. 309rv6 • DOI: 10.1126/scitranslmed.aaa1805
Abstract
The discovery of human induced pluripotent stem cells (hiPSCs) might pave the way toward a long-sought solution for obtaining sufficient numbers of autologous cells for tissue engineering. Several methods exist for generating endothelial cells or perivascular cells from hiPSCs in vitro for use in the building of vascular tissue. We discuss current developments in the generation of vascular progenitor cells from hiPSCs and the assessment of their functional capacity in vivo, opportunities and challenges for the clinical translation of engineered vascular tissue, and modeling of vascular diseases using hiPSC-derived vascular progenitor cells.
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Supplementary Material
Summary
Table S1. Key developments in functional evaluation of hiPSC-ECs and PVCs in vivo
Table S2. Generation of hiPSC-ECs and PVCs.
Table S3. Modeling diseases using hiPSC-ECs and PVCs.
Movie S1. Multiphoton laser scanning image of iPSC-engineered blood vessels in vivo in day 12 cranial window of SCID mouse: Green eGFP HS27-iPSC ECs co-implanted with DsRed 10T1/2 cells.
Movie S2. Multiphoton laser scanning image of iPSC-engineered blood vessels in vivo in day 12 cranial window of SCID mouse: Green eGFP HS27-iPSC ECs co-implanted with DsRed 10T1/2 cells.
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Science Translational Medicine
Volume 7 | Issue 309
October 2015
October 2015
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Copyright © 2015, American Association for the Advancement of Science.
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Received: 28 October 2014
Accepted: 14 September 2015
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