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HUMAN IMMUNOLOGY

Resident memory T cells in human health and disease

Rachael A. Clark
Science Translational Medicine • 7 Jan 2015 • Vol 7, Issue 269 • p. 269rv1 • DOI: 10.1126/scitranslmed.3010641
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Abstract

Resident memory T cells are non-recirculating memory T cells that persist long-term in epithelial barrier tissues, including the gastrointestinal tract, lung, skin, and reproductive tract. Resident memory T cells persist in the absence of antigens, have impressive effector functions, and provide rapid on-site immune protection against known pathogens in peripheral tissues. A fundamentally distinct gene expression program differentiates resident memory T cells from circulating T cells. Although these cells likely evolved to provide rapid immune protection against pathogens, autoreactive, aberrantly activated, and malignant resident memory cells contribute to numerous human inflammatory diseases including mycosis fungoides and psoriasis. This review will discuss both the science and medicine of resident memory T cells, exploring how these cells contribute to healthy immune function and discussing what is known about how these cells contribute to human inflammatory and autoimmune diseases.
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Science Translational Medicine
Volume 7 | Issue 269
January 2015

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Copyright © 2015, American Association for the Advancement of Science.

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Received: 10 September 2014
Accepted: 14 November 2014

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Rachael A. Clark
Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA. E-mail: [email protected]
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