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Commentary
Psychiatric Drug Discovery

Revolution Stalled

Science Translational Medicine
10 Oct 2012
Vol 4, Issue 155
p. 155cm11

Abstract

Drug discovery is at a near standstill for treating psychiatric disorders such as schizophrenia, bipolar disorder, depression, and common forms of autism. Despite high prevalence and unmet medical need, major pharmaceutical companies are deemphasizing or exiting psychiatry, thus removing significant capacity from efforts to discover new medicines. In this Commentary, I develop a view of what has gone wrong scientifically and ask what can be done to address this parlous situation.

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Science Translational Medicine
Volume 4 | Issue 155
October 2012

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Acknowledgments

I thank the members and staff of the Institute of Medicine Forum on Neuroscience and Nervous System Disorders for multiple probing discussions touching on many of the topics discussed here. Funding: This work was supported by the Stanley Foundation. Competing interests: I serve on the Novartis Science Board.

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Steven E. Hyman
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

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