Emerging H5N8 avian influenza viruses
Abstract
The first confirmed outbreak of highly pathogenic avian influenza virus (HPAIV) in birds was documented in Scotland in 1959 with the influenza A H5N1 subtype, although there have been numerous suspected HPAIV outbreaks documented globally since 1878. H5N1 and its genetic reassortants (including H5N2, H5N5, H5N6, and H5N8) have been found to cause thousands of outbreaks worldwide (1, 2) in both farmed poultry and wild birds, with massive mortality. The H5Ny HPAIVs are lethal to most farmed poultry, and culling is often used to prevent further spread. Several of the H5Ny AIVs have zoonotic and pandemic potential because they have been demonstrated to cross the species barrier, transmitting to mammals, including humans. Eurasia and Africa are experiencing a new wave of highly pathogenic H5Ny AIV outbreaks. The zoonotic potential of AIVs warrants continuous, vigilant monitoring to avert further spillovers that could result in disastrous pandemics.
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Science
Volume 372 | Issue 6544
21 May 2021
21 May 2021
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Copyright © 2021, American Association for the Advancement of Science.
This is an article distributed under the terms of the Science Journals Default License.
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Published in print: 21 May 2021
Acknowledgments
This work was supported by National Science and Technology Major Project (2018ZX10101004) and the Academic Promotion Programme of Shandong First Medical University (2019QL006). W.S. is supported by the Taishan Scholars Program of Shandong Province.
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