New mechanisms, new worries
Abstract
Growing levels of resistance to available antimicrobial medicines are causing tens of thousands of deaths each year across the world (1). By 2050, the overall costs associated with antimicrobial resistance (AMR) could reduce global gross domestic product (GDP) by 2 to 3.5% (2). One concern is the development of resistance to the carbapenem antibiotics among Gram-negative bacteria, in particular, the carbapenemase-producing Enterobacteriaceae (CPE) (see the image). Enterobacteriaceae are the source of community- and hospital-acquired infections and commonly cause opportunistic infections, including pneumonia, and sometimes death (3). CPE are resistant to nearly all available antibiotics, with the exception of colistin. Emerging resistance to colistin therefore has troubling implications for patient care.
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References and Notes
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Phumart P., et al., J. Health Syst. Res. 6, 352 (2012).
2
Review on Antimicrobial Resistance, Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations, O'Neill J., chair (UK, December 2014).
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Borer A., et al., Infect. Control Hosp. Epidemiol. 30, 972 (2009).
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Queenan A. M., Bush K., Clin. Microbiol. Rev. 20, 440 (2007).
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Miriagou V., et al., Clin. Microbiol. Infect. 16, 112 (2010).
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Poirel L., Pitout J. D., Nordmann P., Future Microbiol. 2, 501 (2007).
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Antunes N. T., et al., Antimicrob. Agents Chemother. 58, 2119 (2014).
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Bakthavatchalam Y. D., Anandan S., Veeraraghavan B., J. Global Infect. Dis. 8, 41 (2016).
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Albiger B., Glasner C., Struelens M., Grundmann H., Monnet D., Euro Surveill. 20, 30062 (2015).
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Edelstein M. V., et al., Lancet Infect Dis. 13, 867 (2013).
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Giani T., et al., J Clin Microbiol. 53, 3341 (2015).
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Liu Y-Y., Lancet Infect. Dis. 16, 161 (2016).
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Hasman H., et al., Euro Surveill. 20, 30085 (2015).
14
Perrin-Guyomard A., et al., Euro Surveill. 21, 30135 (2016).
Information & Authors
Information
Published In
Science
Volume 351 | Issue 6279
18 March 2016
18 March 2016
Copyright
Copyright © 2016, American Association for the Advancement of Science.
Submission history
Published in print: 18 March 2016
Acknowledgments
We thank A. Andremont for his comments on this article.
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