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Abstract

The antitumor antibiotic, adriamycin, induces severe cardiac toxicity associated with peroxidation of cardiac lipids in mice. Both this lipid peroxidation and cardiac toxicity of adriamycin are reduced by prior treatment of the animals with the free radical scavenger tocopherol. Such treatment with tocopherol does not, however, alter the magnitude or duration of the adriamycin-induced suppression of DNA synthesis in P388 ascites tumor, nor does it diminish the antitumor responsiveness of P388 ascites tumor. These results suggest that adriamycin has at least two mechanisms of tissue damage: one, which involves lipid peroxidation, is blocked by tocopherol and results in cardiac toxicity; the other, which involves binding to DNA, is not antagonized by tocopherol and is responsible for tumor response.

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Science
Volume 197 | Issue 4299
8 July 1977

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Published in print: 8 July 1977

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Charles E. Myers
Clinical Pharmacology Branch, National Cancer Institute, Bethesda, Maryland 20014
William P. McGuire
Combined Modalities Branch, National Cancer Institute, Bethesda, Maryland 20014
Robert H. Liss
Arthur D. Little, Inc., Cambridge, Massachusetts 02166
Ina Ifrim
Arthur D. Little, Inc., Cambridge, Massachusetts 02166
Karen Grotzinger
Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
Robert C. Young
Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014

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