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Functional Role of Type I and Type II Interferons in Antiviral Defense

Ulrike Müller, Ulrich Steinhoff, Luiz F. L. Reis, Silvio Hemmi, Jovan Pavlovic, Rolf M. Zinkernagel, and Michel Aguet
Science • 24 Jun 1994 • Vol 264, Issue 5167 • pp. 1918-1921 • DOI: 10.1126/science.8009221
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Abstract

Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.

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Published In

Science
Volume 264 | Issue 5167
24 June 1994

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© 1994.

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Published in print: 24 June 1994

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Ulrike Müller
Institute of Molecular Biology I, University of Zürich, Hönggerberg, 8093 Zürich, Switzerland.
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Ulrich Steinhoff
Institute of Molecular Biology I, University of Zürich, Hönggerberg, 8093 Zürich, Switzerland.
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Luiz F. L. Reis
Institute of Molecular Biology I, University of Zürich, Hönggerberg, 8093 Zürich, Switzerland.
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Silvio Hemmi
Institute of Molecular Biology I, University of Zürich, Hönggerberg, 8093 Zürich, Switzerland.
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Jovan Pavlovic
Institute of Medical Virology, University of Zürich, 8028 Zürich, Switzerland.
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Rolf M. Zinkernagel
Institute of Molecular Biology I, University of Zürich, Hönggerberg, 8093 Zürich, Switzerland.
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Michel Aguet
Institute of Molecular Biology I, University of Zürich, Hönggerberg, 8093 Zürich, Switzerland.
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