Advertisement

Abstract

A sexually dimorphic cell group is described in the preoptic area of the human hypothalamus. Morphometric analysis revealed that the volume of this nucleus is 2.5 ± 0.6 times (mean ± standard error of the mean) as large in men as in women, and contains 2.2 ± 0.5 times as many cells. Between the ages of 10 and 93 years, the nucleus decreases greatly in volume and in cell number. Although no function has yet been established for this nucleus, it is located within an area that is essential for gonadotropin release and sexual behavior in other mammals.

References

ARENDASH, G.W., EFFECTS OF DISCRETE LESIONS OF THE SEXUALLY DIMORPHIC NUCLEUS OF THE PREOPTIC AREA OR OTHER MEDIAL PREOPTIC REGIONS ON THE SEXUAL-BEHAVIOR OF MALE-RATS, BRAIN RESEARCH BULLETIN 10: 147 (1983).
ARENDASH, G.W., ENHANCEMENT OF SEXUAL-BEHAVIOR IN FEMALE RATS BY NEONATAL TRANSPLANTATION OF BRAIN-TISSUE FROM MALES, SCIENCE 217: 1276 (1982).
AYOUB, D.M., SEX-DIFFERENCES IN DENDRITIC STRUCTURE IN THE PREOPTIC AREA OF THE JUVENILE MACAQUE MONKEY BRAIN, SCIENCE 219: 197 (1983).
BEAN, N.J., EFFECTS OF MEDIAL PREOPTIC LESIONS ON MALE-MOUSE ULTRASONIC VOCALIZATIONS AND COPULATORY-BEHAVIOR, BRAIN RESEARCH BULLETIN 6: 109 (1981).
BLEIER, R, CYTOARCHITECTONIC SEXUAL DIMORPHISMS OF THE MEDIAL PREOPTIC AND ANTERIOR HYPOTHALAMIC AREAS IN GUINEA-PIG, RAT, HAMSTER, AND MOUSE, JOURNAL OF COMPARATIVE NEUROLOGY 212: 118 (1982).
COMMINS, D, ADULT TESTOSTERONE LEVELS INFLUENCE THE MORPHOLOGY OF A SEXUALLY DIMORPHIC AREA IN THE MONGOLIAN GERBIL BRAIN, JOURNAL OF COMPARATIVE NEUROLOGY 224: 132 (1984).
CRUZORIVE, L. M., JOURNAL OF MICROSCOPY-OXFORD 112: 153 (1978).
DELACOSTEUTAMSI.C, SEXUAL DIMORPHISM IN THE HUMAN CORPUS-CALLOSUM, SCIENCE 216: 1431 (1982).
de Vries, G. J., Progress in Brain Research 61 (1984).
GORSKI, R.A., EVIDENCE FOR A MORPHOLOGICAL SEX DIFFERENCE WITHIN MEDIAL PREOPTIC AREA OF RAT-BRAIN, BRAIN RESEARCH 148: 333 (1978).
GORSKI, R.A., EVIDENCE FOR THE EXISTENCE OF A SEXUALLY DIMORPHIC NUCLEUS IN THE PREOPTIC AREA OF THE RAT, JOURNAL OF COMPARATIVE NEUROLOGY 193: 529 (1980).
GORSKI, R.A., CRITICAL ROLE FOR THE MEDIAL PREOPTIC AREA IN THE SEXUAL-DIFFERENTIATION OF THE BRAIN, PROGRESS IN BRAIN RESEARCH 61: 129 (1984).
HART, B.L., MEDIAL PREOPTIC-ANTERIOR HYPOTHALAMIC AREA AND SOCIOSEXUAL BEHAVIOR OF MALE DOGS - COMPARATIVE NEUROPSYCHOLOGICAL ANALYSIS, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 86: 328 (1974).
HINES, M, BIOLOGY OF REPRODUCTION 26: 49a (1982).
Keefer, D. A., Anatomical Neuroendocrinology: 153 (1975).
MALL, F.P., On several anatomical characters of the human brain, said to vary according to race and sex, with aspecial reference to the weight of the frontal lobe., AMERICAN JOURNAL OF ANATOMY 9: 1 (1909).
OOMURA, Y, MEDIAL PREOPTIC AND HYPOTHALAMIC NEURONAL-ACTIVITY DURING SEXUAL-BEHAVIOR OF THE MALE MONKEY, BRAIN RESEARCH 266: 340 (1983).
PFAFF, D, ATLAS OF ESTRADIOL-CONCENTRATING CELLS IN CENTRAL NERVOUS-SYSTEM OF FEMALE RAT, JOURNAL OF COMPARATIVE NEUROLOGY 151: 121 (1973).
RAISMAN, G, SEXUAL DIMORPHISM IN PREOPTIC AREA OF RAT, SCIENCE 173: 731 (1971).
RODRIGUEZSIERRA, J.F., LESIONS OF THE PREOPTIC AREA FACILITATE LORDOSIS BEHAVIOR IN MALE AND FEMALE GUINEA-PIGS, BRAIN RESEARCH BULLETIN 4: 513 (1979).
SHANDER, D, ROLE OF THE PREOPTIC BRAIN IN THE REGULATION OF PREOVULATORY GONADOTROPIN SURGES IN THE HAMSTER, EXPERIMENTAL BRAIN RESEARCH 40: 123 (1980).
Sheridan, P. J., Anatomical Neuroendocrinology: 134 (1975).
SIMERLY, R.B., DEMONSTRATION OF A SEXUAL DIMORPHISM IN THE DISTRIBUTION OF SEROTONIN-IMMUNOREACTIVE FIBERS IN THE MEDIAL PREOPTIC NUCLEUS OF THE RAT, JOURNAL OF COMPARATIVE NEUROLOGY 225: 151 (1984).
Stumpf, W. E., Anatomical Neuroendocrinology: 82 (1975).
SWAAB, D.F., SEXUAL-DIFFERENTIATION OF THE HUMAN-BRAIN - A HISTORICAL-PERSPECTIVE, PROGRESS IN BRAIN RESEARCH 61: 361 (1984).
Swaab, D. F., Topics in Aging Research 2: 71 (1984).
TOBET, S.A., ENDOCRINOLOGY 112 Supplement (1983).
VANDEPOLL, N.E., EFFECT OF MEDIAL PREOPTIC-ANTERIOR HYPOTHALAMIC-LESIONS ON BISEXUAL BEHAVIOR OF THE MALE-RAT, BRAIN RESEARCH BULLETIN 4: 505 (1979).
WATSON, R. E., ANATOMICAL RECORD 205: A210 (1983).
Weibel, E. R., Stereological Methods 1 (1979).
WIEGAND, S.J., PERSISTENT ESTRUS AND BLOCKADE OF PROGESTERONE-INDUCED LH-RELEASE FOLLOWS LESIONS WHICH DO NOT DAMAGE SUPRACHIASMATIC NUCLEUS, ENDOCRINOLOGY 102: 1645 (1978).
Get full access to this article

View all available purchase options and get full access to this article.

Already a Subscriber?

Information & Authors

Information

Published In

Science
Volume 228Issue 470331 May 1985
Pages: 1112 - 1115

History

Published online: 31 May 1985

Permissions

Request permissions for this article.

Authors

Affiliations

D. F. Swaab
Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
E. Fliers
Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands

Metrics & Citations

Metrics

Citations

View Options

Media

Figures

Other

Tables

Share

Information & Authors
Published In
issue cover image
Science
Volume 228|Issue 4703
31 May 1985
Submission history
Published in print:31 May 1985
Metrics & Citations
Article Usage
Altmetrics
Export citation

Select the format you want to export the citation of this publication.

Share
Share article link

Share on social media
Get Access
Log in to view the full text

AAAS Log in

AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions, as well as limited access for those who register for access.

Log in via OpenAthens.
Log in via Shibboleth.
More options

Purchase digital access to this article

Download and print this article for your personal scholarly, research, and educational use.

Purchase this issue in print

Buy a single issue of Science for just $15 USD.

View Options
Tables
References

(0)eLetters

No eLetters have been published for this article yet.

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. eLetters are not edited, proofread, or indexed. Please read our Terms of Service before submitting your own eLetter.