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Abstract

The patterned expression of floral homeotic genes inArabidopsis depends on the earlier action of meristem-identity genes such as LEAFY, which encodes a transcription factor that determines whether a meristem will generate flowers instead of leaves and shoots. The LEAFY protein, which is expressed throughout the flower, participates in the activation of homeotic genes, which are expressed in specific regions of the flower. Analysis of a LEAFY-responsive enhancer in the homeotic geneAGAMOUS indicates that direct interaction of LEAFY with this enhancer is required for its activity in plants. Thus, LEAFY is a direct upstream regulator of floral homeotic genes.

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We are grateful to T. Nguyen for technical assistance. We thank M. Blázquez, M. Deyholos, R. Hong, K. Jones, O. Nilsson, F. Parcy, L. Sieburth, D. Wagner, and M. Yanofsky for discussion, review of the manuscript, and communicating unpublished results. Supported by a fellowship from the Human Frontier Science Program Organization (M.B.), and grants from the NSF and Department of Energy (D.W.). D.W. is a NSF Young Investigator.

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Published In

Science
Volume 285 | Issue 5427
23 July 1999

Submission history

Received: 12 March 1999
Accepted: 3 June 1999
Published in print: 23 July 1999

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Authors

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Maximilian A. Busch*
The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Kirsten Bomblies*
The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Detlef Weigel
The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Notes

*
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: [email protected]

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