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Signals That Regulate Food Intake and Energy Homeostasis

Stephen C. Woods, Randy J. Seeley, Daniel Porte, Jr., and Michael W. Schwartz
Science • 29 May 1998 • Vol 280, Issue 5368 • pp. 1378-1383 • DOI: 10.1126/science.280.5368.1378
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Abstract

Feeding behavior is critical for survival. In addition to providing all of the body's macronutrients (carbohydrates, lipids, and proteins) and most micronutrients (minerals and vitamins), feeding behavior is a fundamental aspect of energy homeostasis, the process by which body fuel stored in the form of adipose tissue is held constant over long intervals. For this process to occur, the amount of energy consumed must match precisely the amount of energy expended. This review focuses on the molecular signals that modulate food intake while integrating the body's immediate and long-term energy needs.

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Supported by grants from the NIH (DK 17844, DK 54080, DK 54890, DK 12829, DK 52989, and NS 32273), the Diabetes Endocrinology Research Center and Clinical Nutrition Research Unit of the University of Washington, and the Merit Review Program of the Department of Veterans Affairs and funds from the Division of Metabolic Diseases, Hoffmann-La Roche, Nutley, NJ.

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Science
Volume 280 | Issue 5368
29 May 1998

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Published in print: 29 May 1998

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Stephen C. Woods*
S. C. Woods and R. J. Seeley are in the Department of Psychiatry, University of Cincinnati Medical Center, Post Office Box 670559, Cincinnati, OH 45267–0559, USA. D. Porte Jr. and M. W. Schwartz are in the Department of Medicine, University of Washington and Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA.
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Randy J. Seeley
S. C. Woods and R. J. Seeley are in the Department of Psychiatry, University of Cincinnati Medical Center, Post Office Box 670559, Cincinnati, OH 45267–0559, USA. D. Porte Jr. and M. W. Schwartz are in the Department of Medicine, University of Washington and Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA.
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Daniel Porte, Jr.
S. C. Woods and R. J. Seeley are in the Department of Psychiatry, University of Cincinnati Medical Center, Post Office Box 670559, Cincinnati, OH 45267–0559, USA. D. Porte Jr. and M. W. Schwartz are in the Department of Medicine, University of Washington and Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA.
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Michael W. Schwartz
S. C. Woods and R. J. Seeley are in the Department of Psychiatry, University of Cincinnati Medical Center, Post Office Box 670559, Cincinnati, OH 45267–0559, USA. D. Porte Jr. and M. W. Schwartz are in the Department of Medicine, University of Washington and Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA.
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Notes

*
To whom correspondence should be addressed. E-mail: [email protected]

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