Receptor Tails Unlock Developmental Checkpoints for B Lymphocytes
Abstract
Two reports, one previously published in Science (Gong and Nussenzweig, 19 April, p. 411) and one in this week's issue (Torres et al., p. 1804), report the surprising phenotypes of genetically engineered (knockout) mice missing the Ig-alpha and Ig-beta accessory proteins of the B cell antigen receptor. DeFranco and Roth discuss in their Perspective how the characteristics of these mice reveal two new checkpoints in the developmental pathway of the B cell.
REFERENCES
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Published In
Science
Volume 272 | Issue 5269
21 June 1996
21 June 1996
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© 1996 American Association for the Advancement of Science.
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Published in print: 21 June 1996
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