Structural Evidence for Functional Domains in the Rat Hippocampus
Abstract
The hippocampus has two major outputs: multisynaptic pathways to the cerebral cortex and a massive descending projection directly to the lateral septal part of the basal ganglia. Here it is shown that the descending output is organized in such a way that different hippocampal regions map in an orderly way onto hypothalamic systems mediating the expression of different classes of goal-oriented behavior. This mapping is characterized by a unidirectional hippocampo-lateral septal projection and then by bidirectional lateral septo-hypothalamic projections, all topographically organized. The connectional evidence predicts that information processing in different regions of the hippocampus selectively influences the expression of different classes of behavior.
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Science
Volume 272 | Issue 5267
7 June 1996
7 June 1996
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© 1996 American Association for the Advancement of Science.
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Published in print: 7 June 1996
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