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Abstract

The hippocampus has two major outputs: multisynaptic pathways to the cerebral cortex and a massive descending projection directly to the lateral septal part of the basal ganglia. Here it is shown that the descending output is organized in such a way that different hippocampal regions map in an orderly way onto hypothalamic systems mediating the expression of different classes of goal-oriented behavior. This mapping is characterized by a unidirectional hippocampo-lateral septal projection and then by bidirectional lateral septo-hypothalamic projections, all topographically organized. The connectional evidence predicts that information processing in different regions of the hippocampus selectively influences the expression of different classes of behavior.

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Published In

Science
Volume 272 | Issue 5267
7 June 1996

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Published in print: 7 June 1996

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P. Y. Risold
Program in Neural, Informational, and Behavioral Sciences and the Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-2520, USA.
L. W. Swanson*
Program in Neural, Informational, and Behavioral Sciences and the Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-2520, USA.

Notes

*
To whom correspondence should be addressed.

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