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Chain Migration of Neuronal Precursors

Carlos Lois, Jose-Manuel García-Verdugo, and Arturo Alvarez-BuyllaAuthors Info & Affiliations
Science
16 Feb 1996
Vol 271, Issue 5251
pp. 978-981
DOI: 10.1126/science.271.5251.978
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Abstract

In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.

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Science
Volume 271 | Issue 5251
16 February 1996

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© 1996 American Association for the Advancement of Science.

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Published in print: 16 February 1996

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Authors

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Carlos Lois
C. Lois and A. Alvarez-Buylla, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
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Jose-Manuel García-Verdugo
J.-M. García-Verdugo, Facultad de Biológicas, Universitas Valencia, Burjassot, Valencia 46100, Spain.
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Arturo Alvarez-Buylla(1)
C. Lois and A. Alvarez-Buylla, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
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Notes

(1)
To whom correspondence should be addressed.

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