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The Neutrophil-Activating Protein (NAP-1) Is Also Chemotactic for T Lymphocytes

Christian Grønhøj Larsen, Arthur O. Anderson, Ettore Appella, Joost J. Oppenheim, and Kouji Matsushima
Science • 17 Mar 1989 • Vol 243, Issue 4897 • pp. 1464-1466 • DOI: 10.1126/science.2648569
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Abstract

T lymphocyte chemotactic factor (TCF) was purified to homogeneity from the conditioned media of phytohemagglutinin-stimulated human blood mononuclear leukocytes by a sequence of chromatography procedures. The amino-terminal amino acid sequence of the purified TCF showed identity with neutrophil-activating protein (NAP-1). Both TCF and recombinant NAP-1 (rNAP-1) were chemotactic for neutrophils and T lymphocytes in vitro supporting the identity of TCF with NAP-1. Injection of rNAP-1 into lymphatic drainage areas of lymph nodes in Fisher rats caused accelerated emigration of only lymphocytes in high endothelial venules. Intradermal injection of rNAP-1 caused dose-dependent accumulation of neutrophils and lymphocytes.

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Science
Volume 243 | Issue 4897
17 March 1989

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© 1989.

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Published in print: 17 March 1989

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Christian Grønhøj Larsen
Laboratory of Molecular Imnmunorepulation, Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21701.
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Arthur O. Anderson
Laboratory of Respiratory and Mucosal Immunity, Disease Assessment Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21701.
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Ettore Appella
Laboratory of Cell Biology, National Cancer Institute, Bethesda, MD 20892.
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Joost J. Oppenheim
Laboratory of Molecular Imnmunorepulation, Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21701.
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Kouji Matsushima
Laboratory of Molecular Imnmunorepulation, Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21701.
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