A Model for the Adjustment of the Mitotic Clock by Cyclin and MPF Levels
Abstract
A mathematical model of cell cycle progression is presented, which integrates recent biochemical information on the interaction of the maturation promotion factor (MPF) and cyclin. The model retrieves the dynamics observed in early embryos and explains how multiple cycles of MPF activity can be produced and how the internal clock that determines durations and number of cycles can be adjusted by modulating the rate of change in MPF or cyclin concentrations. Experiments are suggested for verifying the role of MPF activity in determining the length of the somatic cell cycle.
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Published In
Science
Volume 251 | Issue 4997
1 March 1991
1 March 1991
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© 1991.
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Published in print: 1 March 1991
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- Mathematical Analysis of a Model of the Mitotic Clock, Science, 254, 5028, (122-123), (1991)./doi/10.1126/science.1833817
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