A number of drugs that are metabolized through the action of enzymes present in liver microsomes in the adult rabbit are not metabolized in livers of newborn rabbits. The development of metabolic pathways during a period of 4 weeks is presented. Evidence is given for the presence in livers of baby rabbits of inhibitors of some of these drug-enzyme systems.
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MITOMA, C, ENZYMATIC HYDROXYLATION OF AROMATIC COMPOUNDS, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 61: 431 (1956).
POTTER, V.R., ENZYME CHANGES DURING GROWTH AND DIFFERENTIATION IN THE TISSUES OF THE NEWBORN RAT, CANCER RESEARCH 5: 21 (1945).
SALZMAN, N.P., PHYSIOLOGICAL DISPOSITION AND FATE OF CHLORPROMAZINE AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL MATERIAL, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 118: 46 (1956).
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Volume 129 | Issue 3353
3 April 1959
3 April 1959
Published in print: 3 April 1959
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