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Abstract

A number of drugs that are metabolized through the action of enzymes present in liver microsomes in the adult rabbit are not metabolized in livers of newborn rabbits. The development of metabolic pathways during a period of 4 weeks is presented. Evidence is given for the presence in livers of baby rabbits of inhibitors of some of these drug-enzyme systems.

References

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Published In

Science
Volume 129 | Issue 3353
3 April 1959

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Published in print: 3 April 1959

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James R. Fouts
Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City
Richard H. Adamson
Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City

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