Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Abstract
The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.
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We thank A. Rodi and M. Pelegrin for expert technical assistance; I. Gresser for helpful comments and critical review of the manuscript; and D. Frucht, C. Anderson, and T. Pokrovska for critically reading the manuscript. Supported by the Association pour la Recherche sur le Cancer (ARC) through the Alliance pour la Recherche sur le Cancer network (ARECA), INSERM, Action Concertée Incitative ACI IMPBio, Université Paris-Descartes Paris 5, and the Austrian Federal Ministry of Education, Science and Culture (GBN-AU project Bioinformatics Integration Network).
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Science
Volume 313 | Issue 5795
29 September 2006
29 September 2006
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American Association for the Advancement of Science.
Submission history
Received: 25 April 2006
Accepted: 30 August 2006
Published in print: 29 September 2006
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