Type 1 Interferons and the Virus-Host Relationship: A Lesson in Détente
Abstract
The interface between an infectious agent and its host represents the ultimate battleground for survival: The microbe must secure a niche for replication, whereas the host must limit the pathogen's advance. Among the host's arsenal of antimicrobial factors, the type 1 interferons (IFNs) induce potent defense mechanisms against viruses and are key in the host-virus standoff. Viruses have evolved multiple tricks to avoid the immediate antiviral effects of IFNs and, in turn, hosts have adapted use of this innate cytokine system to galvanize multiple additional layers of immune defense. The plasticity that exists in these interactions provides us with a lesson in détente.
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References and Notes
1
R. Medzhitov, C. A. Janeway Jr., Semin. Immunol.10, 351 (1998).
2
S. S. Diebold, T. Kaisho, H. Hemmi, S. Akira, C. Reis e Sousa, Science303, 1529 (2004).
3
F. Heil et al., Science303, 1526 (2004).
4
J. M. Lund et al., Proc. Natl. Acad. Sci. U.S.A.101, 5598 (2004).
5
H. Hemmi et al., Nature408, 740 (2000).
6
L. Alexopoulou, A. C. Holt, R. Medzhitov, R. A. Flavell, Nature413, 732 (2001).
7
T. Kawai, S. Akira, Cell Death Differ.13, 816 (2006).
8
M. G. Wathelet et al., Mol. Cell1, 507 (1998).
9
I. Marie, J. E. Durbin, D. E. Levy, EMBO J.17, 6660 (1998).
10
H. Kato et al., Immunity23, 19 (2005).
11
M. Yoneyama et al., Nat. Immunol.5, 730 (2004).
12
R. B. Seth, L. Sun, C. K. Ea, Z. J. Chen, Cell122, 669 (2005).
13
T. Kawai et al., Nat. Immunol.6, 981 (2005).
14
L. G. Xu et al., Mol. Cell19, 727 (2005).
15
E. Meylan et al., Nature437, 1167 (2005).
16
K. J. Ishii et al., Nat. Immunol.7, 40 (2006).
17
D. B. Stetson, R. Medzhitov, Immunity24, 93 (2006).
18
M. M. Brierley, E. N. Fish, J. Interferon Cytokine Res.22, 835 (2002).
19
L. C. Platanias, Nat. Rev. Immunol.5, 375 (2005).
20
C. A. Biron, G. C. Sen, in Fields Virology, Fourth Edition, D. M. Knipe et al., Eds. (Lippincott, Williams, and Wilkins, Philadelphia, 2001), pp. 321–351.
21
K. B. Nguyen et al., Nat. Immunol.1, 70 (2000).
22
K. B. Nguyen et al., Science297, 2063 (2002).
23
S. S. Cho et al., J. Immunol.157, 4781 (1996).
24
B. Hahm, M. J. Trifilo, E. I. Zuniga, M. B. Oldstone, Immunity22, 247 (2005).
25
C. E. Samuel, Clin. Microbiol. Rev.14, 778 (2001).
26
A. Zhou, J. M. Paranjape, S. D. Der, B. R. Williams, R. H. Silverman, Virology258, 435 (1999).
27
M. Dalod et al., J. Exp. Med.197, 885 (2003).
28
C. K. Lee et al., J. Immunol.165, 3571 (2000).
29
K. B. Nguyen et al., J. Immunol.169, 4279 (2002).
30
C. L. Karp, C. A. Biron, D. N. Irani, Immunol. Today21, 24 (2000).
31
X. Zhang, S. Sun, I. Hwang, D. F. Tough, J. Sprent, Immunity8, 591 (1998).
32
J. F. Bromberg, C. M. Horvath, Z. Wen, R. D. Schreiber, J. E. Darnell Jr., Proc. Natl. Acad. Sci. U.S.A.93, 7673 (1996).
33
M. P. Gil, R. Salomon, J. Louten, C. A. Biron, Blood107, 987 (2006).
34
M. P. Gil et al., Proc. Natl. Acad. Sci. U.S.A.98, 6680 (2001).
35
C. V. Ramana et al., EMBO J.19, 263 (2000).
36
G. A. Kolumam, S. Thomas, L. J. Thompson, J. Sprent, K. Murali-Krishna, J. Exp. Med.202, 637 (2005).
37
A. Gallimore et al., J. Exp. Med.187, 1383 (1998).
38
R. Gimeno, C. K. Lee, C. Schindler, D. E. Levy, Mol. Cell. Biol.25, 5456 (2005).
39
C. K. Lee, E. Smith, R. Gimeno, R. Gertner, D. E. Levy, J. Immunol.164, 1286 (2000).
40
Y. Tanabe et al., J. Immunol.174, 609 (2005).
41
J. Talon et al., Proc. Natl. Acad. Sci. U.S.A.97, 4309 (2000).
42
Y. Xiang et al., J. Virol.76, 5251 (2002).
43
J. Andrejeva et al., Proc. Natl. Acad. Sci. U.S.A.101, 17264 (2004).
44
K. Li et al., Proc. Natl. Acad. Sci. U.S.A.102, 2992 (2005).
45
G. Unterstab et al., Proc. Natl. Acad. Sci. U.S.A.102, 13640 (2005).
46
J. A. Symons, A. Alcami, G. L. Smith, Cell81, 551 (1995).
47
C. M. Horvath, Eur. J. Biochem.271, 4621 (2004).
48
O. Haller, G. Kochs, F. Weber, Virology344, 119 (2006).
49
M. G. Katze, Y. He, M. Gale Jr., Nat. Rev. Immunol.2, 675 (2002).
50
G. K. Geiss et al., Proc. Natl. Acad. Sci. U.S.A.99, 10736 (2002).
51
T. M. Tumpey et al., Science310, 77 (2005).
52
S. Dupuis et al., Nat. Genet.33, 388 (2003).
53
J. E. Durbin, R. Hackenmiller, M. C. Simon, D. E. Levy, Cell84, 443 (1996).
54
S. M. Karst, C. E. Wobus, M. Lay, J. Davidson, H. W. Virgin, Science299, 1575 (2003).
55
M. A. Meraz et al., Cell84, 431 (1996).
56
Work in A.G.-S.'s lab is supported by NIH grants R01AI46954, P01AI52106, P01AI58113, U54AI57158, and U19AI62623, and DOD grant W81XWH-04-1-0876. Work in C.A.B.'s lab is supported by NIH grants RO1CA41268 and RO1AI55677. In memory of Theresa P. Biron.
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Science
Volume 312 | Issue 5775
12 May 2006
12 May 2006
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