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Special Reviews

Type 1 Interferons and the Virus-Host Relationship: A Lesson in Détente

Science
12 May 2006
Vol 312, Issue 5775
pp. 879-882

Abstract

The interface between an infectious agent and its host represents the ultimate battleground for survival: The microbe must secure a niche for replication, whereas the host must limit the pathogen's advance. Among the host's arsenal of antimicrobial factors, the type 1 interferons (IFNs) induce potent defense mechanisms against viruses and are key in the host-virus standoff. Viruses have evolved multiple tricks to avoid the immediate antiviral effects of IFNs and, in turn, hosts have adapted use of this innate cytokine system to galvanize multiple additional layers of immune defense. The plasticity that exists in these interactions provides us with a lesson in détente.

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Work in A.G.-S.'s lab is supported by NIH grants R01AI46954, P01AI52106, P01AI58113, U54AI57158, and U19AI62623, and DOD grant W81XWH-04-1-0876. Work in C.A.B.'s lab is supported by NIH grants RO1CA41268 and RO1AI55677. In memory of Theresa P. Biron.

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Published In

Science
Volume 312 | Issue 5775
12 May 2006

Submission history

Published in print: 12 May 2006

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Authors

Affiliations

Adolfo García-Sastre
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Christine A. Biron*
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA.

Notes

*
To whom correspondence should be addressed. E-mail: [email protected]

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