Genome Sequence of Theileria parva, a Bovine Pathogen That Transforms Lymphocytes
Abstract
We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.
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Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.
32
We thank T. Irvin, O. Ole-MoiYoi, T. Musoke, C. Sugimoto, H. Leitch, R. von Kaufmann, S. MacMillan, R. Koenig, M. Brown, R. Ndegwa, L. Thairo, B. Anyona, T. Akinyemi, the TIGR conferences staff, the Secretariat of the Consultative Group for International Agricultural Research, and the research staff of the International Livestock Research Institute (ILRI). Supported by the TIGR Board of Trustees, ILRI, J. C. Venter, the Rockefeller Foundation, the U.S. Agency for International Development, and the UK Department for International Development.
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Science
Volume 309 | Issue 5731
1 July 2005
1 July 2005
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American Association for the Advancement of Science.
Submission history
Received: 31 January 2005
Accepted: 5 May 2005
Published in print: 1 July 2005
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www.sciencemag.org/cgi/content/full/309/5731/134/DC1
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Tables S1 to S3
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