Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva
Abstract
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.
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We acknowledge the support of the Wellcome Trust Sanger Institute core sequencing and informatics groups. We thank N. Zidane and S. Duthoy for sequencing the macroschizont ESTs and V. Heussler and I. Roditi for helpful advice with this manuscript. The sequence and annotation of T. annulata genome have been submitted to the EMBL databases with consecutive accession numbers between CR940346 and CR940353; they can be viewed at www.GeneDB.org. The EST sequences from all three life-cycle stages have been submitted to the EMBL database with consecutive accession numbers between AJ920420 and AJ936931. This work was supported by the Wellcome Trust.
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Published In
Science
Volume 309 | Issue 5731
1 July 2005
1 July 2005
Copyright
American Association for the Advancement of Science.
Submission history
Received: 31 January 2005
Accepted: 5 May 2005
Published in print: 1 July 2005
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www.sciencemag.org/cgi/content/full/309/5731/131/DC1
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Tables S1 to S9
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