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Immunity, Inflammation, and Allergy in the Gut

Thomas T. MacDonald and Giovanni Monteleone
Science • 25 Mar 2005 • Vol 307, Issue 5717 • pp. 1920-1925 • DOI: 10.1126/science.1106442
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Abstract

The gut immune system has the challenge of responding to pathogens while remaining relatively unresponsive to food antigens and the commensal microflora. In the developed world, this ability appears to be breaking down, with chronic inflammatory diseases of the gut commonplace in the apparent absence of overt infections. In both mouse and man, mutations in genes that control innate immune recognition, adaptive immunity, and epithelial permeability are all associated with gut inflammation. This suggests that perturbing homeostasis between gut antigens and host immunity represents a critical determinant in the development of gut inflammation and allergy.
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The authors wish to thank L. Sollid for advice and A. Bateman for assistance with the illustrations. T.T.M. receives payment for consultancy to Danone UK Ltd. and Oxagen Ltd.

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Science
Volume 307 | Issue 5717
25 March 2005

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American Association for the Advancement of Science.

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Published in print: 25 March 2005

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Authors

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Thomas T. MacDonald†,*
Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK.
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Giovanni Monteleone
Dipartimento di Medicina Interna e Centro di Eccellenza per lo Studio delle Malattie Complesse e Multifattoriali, Università Tor Vergata, Rome, Italy.
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Notes

† To whom correspondence should be addressed. E-mail: [email protected]

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