Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

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We thank R. Desimone and members of the Lu laboratory for the thoughtful comments and suggestions, and Regeneron Pharmaceuticals for providing recombinant BDNF. Supported by the NICHD intramural research program (B.L.) and NIH grant NS30658 (B.L.H.). Molecular interaction data have been deposited in the Biomolecular Interaction Network Database with accession code 153566.

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Science

Volume 306 | Issue 5695
15 October 2004

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American Association for the Advancement of Science.

Submission history

Received: 10 May 2004

Accepted: 26 August 2004

Published in print: 15 October 2004

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Petti T. Pang

Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development (NICHD), Bethesda, MD 20892, USA.

Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Henry K. Teng

Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.

Eugene Zaitsev

Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development (NICHD), Bethesda, MD 20892, USA.

Newton T. Woo

Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development (NICHD), Bethesda, MD 20892, USA.

Kazuko Sakata

Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development (NICHD), Bethesda, MD 20892, USA.

Shushuang Zhen

Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.

Kenneth K. Teng

Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.

Wing-Ho Yung

Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Barbara L. Hempstead

Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.

Bai Lu^*

Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development (NICHD), Bethesda, MD 20892, USA.