V1 Neurons Signal Acquisition of an Internal Representation of Stimulus Location
Abstract
A fundamental aspect of visuomotor behavior is deciding where to look or move next. Under certain conditions, the brain constructs an internal representation of stimulus location on the basis of previous knowledge and uses it to move the eyes or to make other movements. Neuronal responses in primary visual cortex were modulated when such an internal representation was acquired: Responses to a stimulus were affected progressively by sequential presentation of the stimulus at one location but not when the location was varied randomly. Responses of individual neurons were spatially tuned for gaze direction and tracked the Bayesian probability of stimulus appearance. We propose that the representation arises in a distributed cortical network and is associated with systematic changes in response selectivity and dynamics at the earliest stages of cortical visual processing.
Get full access to this article
View all available purchase options and get full access to this article.
Already a Subscriber?Sign In
Supplementary Material
File (sharmasom.pdf)
References and Notes
1
Materials and methods are available on Science Online.
2
A. W. F. Edwards, Likelihood (Cambridge Univ. Press, Cambridge, 1972).
3
R. H. S. Carpenter, M. L. Williams, Nature377, 59 (1995).
4
E. Kowler, in Eye Movements and Their Role in Visual and Cognitive Processes, E. Kowler, Ed. (Elsevier, Amsterdam, 1990), vol 4, chap. 1, pp. 1–63.
5
R. D. Luce, Response Times: Their Role in Inferring Elementary Mental Organization (Oxford, New York, 1986), pp. 253–268.
6
R. A. Andersen, Annu. Rev. Neurosci.12, 377 (1997).
7
J. D. Schall, Nature Rev. Neurosci.2, 33 (2001).
8
P. W. Glimcher, Trends Neurosci.24, 654 (2001).
9
M. N. Shadlen, W. T. Newsome, J. Neurophysiol.86, 1916 (2001).
10
M. E. Goldberg, J. Bisley, K. D. Powell, J. Gottlieb, M. Kusunoki, Ann. N.Y. Acad. Sci.956, 205 (2002).
11
M. A. Sommer, R. H. Wurtz, Science296, 1480 (2002).
12
J. Schlag, P. Dassonville, M. Schlag-Rey, J. Neurophysiol.79, 64 (1998).
13
K. Toyama, Y. Komatsu, K. Shibuki, J. Neurophysiol.51, 649 (1984).
14
T. G. Weyand, J. G. Malpeli, J. Neurophysiol.69, 2258 (1993).
15
Y. Trotter, S. Celebrini, Nature398, 239 (1999).
16
P. Rosenbluth, J. M. Allman, Neuron33, 143 (2002).
17
P. M. Schiller, E. J. Tehovnik, Prog. Brain Res.134, 127 (2001).
18
The cell of Fig. 2B similarly showed no change in the trial-by-trial IRI at the left and center gaze directions.
19
R. Lal, M. J. Friedlander, Science243, 93 (1989).
20
P. R. Roelfsema, V. A. Lamme, H. Spekreijse, Nature395, 376 (1998).
21
D. C. Somers, A. M. Dale, A. E. Seiffert, R. B. H. Tootell, Proc. Natl. Acad. Sci. U.S.A.96, 1663 (1999).
22
M. I. Posner, C. D. Gilbert, Proc. Natl. Acad. Sci. U.S.A.96, 2585 (1999).
23
R. B. H. Tootell, N. Hadjikhani, Nature Neurosci.3, 206 (2000).
24
A. Schoups, R. Vogels, N. Qian, G. A. Orban, Nature412, 549 (2001).
25
C. D. Gilbert, M. Sigman, R. E. Crist, Neuron31, 681 (2001).
26
D. Ress, D. J. Heeger, Nature Neurosci.6, 414 (2003).
27
P. A. Salin, J. Bullier, Physiol. Rev.75, 107 (1995).
28
D. J. Felleman, D. C. Van Essen, Cereb. Cortex1, 1 (1991).
29
D. C. Lyon, J. H. Kaas, Neuron33, 453 (2002).
30
R. A. Andersen, G. K. Essick, R. M. Siegel, Science230, 456 (1985).
31
R. J. Krauzlis, C. S. Stone, Trends Neurosci.22, 544 (1999).
32
C. L. Colby, J. R. Duhamel, M. E. Goldberg, Cereb. Cortex5, 470 (1995).
33
K. Nakamura, C. L. Colby, Proc. Natl. Acad. Sci. U.S.A.99, 4026 (2002).
34
S. Ben Hamed, J. R. Duhamel, Exp. Brain Res.142, 512 (1998).
35
B. Gaymard, C. J. Ploner, S. Rivaud, A. I. Vermersch, C. Pierrot-Deseilligny, Exp. Brain Res.123, 159 (1998).
36
D. C. Somers, S. B. Nelson, M. Sur, J. Neurosci.15, 5448 (1995).
37
V. Dragoi, J. Sharma, E. K. Miller, M. Sur, Nature Neurosci.5, 883 (2002).
38
We thank P. Sinha for insightful discussions and comments and J. Schummers, J. Mariño, B. Scott, and D. Lyon for careful reading of the manuscript and suggestions. Supported by a fellowship from the McDonnell-Pew Foundation (V.D.) and grants from NIH (M.S.).
Information & Authors
Information
Published In
Science
Volume 300 | Issue 5626
13 June 2003
13 June 2003
Copyright
American Association for the Advancement of Science.
Submission history
Received: 19 December 2002
Accepted: 8 May 2003
Published in print: 13 June 2003
Authors
Metrics & Citations
Metrics
Article Usage
Altmetrics
Citations
Export citation
Select the format you want to export the citation of this publication.
Cited by
- Predictive Codes for Forthcoming Perception in the Frontal Cortex, Science, 314, 5803, (1311-1314), (2006)./doi/10.1126/science.1132028
Loading...
View Options
Get Access
Log in to view the full text
AAAS login provides access to Science for AAAS Members, and access to other journals in the Science family to users who have purchased individual subscriptions.
- Become a AAAS Member
- Activate your AAAS ID
- Purchase Access to Other Journals in the Science Family
- Account Help
Log in via OpenAthens.
Log in via Shibboleth.
More options
Purchase digital access to this article
Download and print this article for your personal scholarly, research, and educational use.
Buy a single issue of Science for just $15 USD.
View options
PDF format
Download this article as a PDF file
Download PDF