Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Abstract
Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector levels of lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.
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We thank J. Altman for modified H-2Kb cDNA and E. Pamer for β2-microglobulin constructs. Supported by U.S. Public Health Service (USPHS) grants DK45260 and AI41576, by USPHS training grant T32-AI07080 (D.M. and V.V.), and by a collaborative grant from the Edward Jenner Institute for Vaccine Research and a C. J. Martin Fellowship (007151) (A.L.M.).
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Science
Volume 291 | Issue 5512
23 March 2001
23 March 2001
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Received: 8 January 2001
Accepted: 16 February 2001
Published in print: 23 March 2001
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