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Although DNA provides the blueprint, proteins are the real workhorses that build our bodies. The latest proteomics technologies can now analyze thousands of proteins simultaneously providing unique insights.
Culture and topography also play important roles
Evidence continues to emerge for the production and low-level accumulation of molecular
oxygen (O2) at Earth’s surface before the Great Oxidation Event. Quantifying this early O2 has proven difficult. Here, we use the distribution and isotopic composition ...
Hypoxia-inducible factor 2α (HIF2α) antagonists are effective against clear cell renal
cell carcinomas (ccRCCs) that highly express HIF2α. To identify potential drug targets
in HIF2αlow/− ccRCC, we constructed an epigenetic-focused single-guide RNA ...
Huntington’s disease (HD) is a hereditary neurodegenerative disorder of the basal
ganglia for which disease-modifying treatments are not yet available. Although gene-silencing
therapies are currently being tested, further molecular mechanisms must be ...
Mutant isocitrate-dehydrogenase 1 (mIDH1) synthesizes the oncometabolite 2-hydroxyglutarate (2HG), which elicits epigenetic
reprogramming of the glioma cells’ transcriptome by inhibiting DNA and histone demethylases.
We show that the efficacy of immune-...
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic, chemoresistant malignancy
and is characterized by a dense, desmoplastic stroma that modulates PDAC progression.
Here, we visualized transient manipulation of focal adhesion kinase (FAK), ...
Pure spin currents can be generated via thermal excitations of magnons. These magnon
spin currents serve as carriers of information in insulating materials, and controlling
them using electrical means may enable energy efficient information processing. ...
The use of implantable medical devices, including cardiac pacemakers and brain pacemakers,
is becoming increasingly prevalent. However, surgically replacing batteries owing
to their limited lifetime is a drawback of those devices. Such an operation poses
...
Klara and the Sun by Kazuo Ishiguro is reviewed.
State-of-the-art technologies for hand (and finger) motion tracking do not always
provide accurate and robust tracking. For example, severe occlusions can affect tracking
with vision sensors, electromagnetic interference affects tracking with inertial ...
COVID-19 mortality increases markedly with age and is also substantially higher among
Black, Indigenous, and People of Color (BIPOC) populations in the United States. These
two facts can have conflicting implications because BIPOC populations are younger
...
The transfer of mitochondria between cells has recently been revealed as a spontaneous
way to protect the injured cells. However, the utilization of this natural transfer
process for disease treatment is so far limited by its unsatisfactory transfer ...
Inhibition of autophagy has been proposed as a potential therapy for individuals with
cancer. However, current lysosomotropic autophagy inhibitors have demonstrated limited
efficacy in clinical trials. Therefore, validation of novel specific autophagy ...
Apolipoprotein E (APOE) genetic variants have been shown to modify Alzheimer’s disease (AD) risk. We previously
identified an APOE3 variant (APOE3-V236E), named APOE3-Jacksonville (APOE3-Jac), associated with healthy brain aging and reduced risk for AD ...
Exoskeletons can enhance human mobility, but we still know little about why they are
effective. For example, we do not know the relative importance of training, how much
is required, or what type is most effective; how people adapt with the device; or
the ...