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Retinoic acid for gut health
Commensal-derived retinoic acid protects mice against infection by priming the innate
defenses of intestinal epithelial cells.
The essential micronutrient zinc regulates immune responses by affecting signaling
pathways. In activated monocytes and macrophages, signaling networks mediate the metabolic
reprogramming that meets the demands of participation in immune responses. Here, ...
SARS-CoV-2 evolution threatens vaccine- and natural infection-derived immunity as
well as the efficacy of therapeutic antibodies. To improve public health preparedness,
we sought to predict which existing amino acid mutations in SARS-CoV-2 might ...
After ligand stimulation, many G protein–coupled receptors (GPCRs) undergo β-arrestin–dependent
desensitization, during which they are internalized and either degraded or recycled
to the plasma membrane. Some GPCRs are not subject to this type of ...
New report asks federal agencies to reconcile policies
The ability to fully 3D-print active electronic and optoelectronic devices will enable
unique device form factors via strategies untethered from conventional microfabrication
facilities. Currently, the performance of 3D-printed optoelectronics can suffer ...
The spleen is a compartmentalized organ that serves as a blood filter and safeguard
of systemic immune surveillance. Labyrinthine networks of fibroblastic stromal cells
construct complex niches within the white pulp and red pulp that are important for
...
Engineered nanoparticles are advantageous for biotechnology applications including
biomolecular sensing and delivery. However, testing compatibility and function of
nanotechnologies in biological systems requires a heuristic approach, where unpredictable
...
Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities.
It is appreciated that different tissues instruct specialized macrophage functions.
However, individual tissues contain heterogeneous subpopulations, and how these ...
Despite being the target of extensive research efforts due to the COVID-19 (coronavirus
disease 2019) pandemic, relatively little is known about the dynamics of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) replication within cells. We ...
The efficacy and safety of a chemotherapy regimen fundamentally depends on its pharmacokinetics.
This is currently measured based on blood samples, but the abnormal vasculature and
physiological heterogeneity of the tumor microenvironment can produce ...
We pursued the hypothesis that specific glycans can be used to distinguish breast
cancer stem cells (CSCs) and influence their function. Comparison of CSCs and non-CSCs
from multiple breast cancer models revealed that CSCs are distinguished by expression
...
To date, effective therapeutic treatments that confer strong attenuation against coronaviruses
(CoVs) remain elusive. Among potential drug targets, the helicase of CoVs is attractive
due to its sequence conservation and indispensability. We rely on ...
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound dysregulation
of the innate immune system. This knowledge has emerged from the large body of single-cell
omics studies of patients with COVID-19, which have provided one of the ...
Global warming increases the number and severity of deadly heatwaves. Recent heatwaves
often coincided with soil droughts that intensify air temperature but lower air humidity.
Since lowering air humidity may reduce human heat stress, the net impact of ...