COVER An ash and gas plume rises from Hunga volcano, Tonga, on 14 January 2022. Global geophysical observations reveal that the climactic eruption that followed on 15 January produced a broad range of atmospheric waves, with pressure wave amplitudes comparable with those from the 1883 Krakatau eruption. While propagating over the world’s oceans, the remarkable atmospheric waves generated complex fast-traveling tsunamis. See pages 30, 91, and 95.

Photo: Taaniela Kula, Tonga Geological Services

ONLINE COVER Pharmaceutical researchers visualize and quantify protein level change in transplanted human organoids, tiny tissue cultures from stem cells. Determining whether new drugs will have the desired effect in humans has been a challenge during preclinical research. Westerling-Bui et al. approached this challenge by introducing human kidney organoids in mice to test a new drug, GFB-887. Their strategy could pave the way to establish a drug’s efficacy in humans during preclinical studies. Credit: Westerling-Bui et al./Science Advances

ONLINE COVER Sex Bias and CD8 T Cell Exhaustion in Cancer. This month’s cover illustration shows male and female silhouettes between layers of cancerous tissue. These objects are wrapped in projected images of multicolor immunofluorescence staining of mouse bladder tumor tissue. The featured Research Article by Kwon et al. identifies T cell–intrinsic effects of androgen as a contributor to sex bias in CD8 T cell–mediated tumor immunity. A related Focus by Bevilacqua and Ho discusses how androgen receptor effects contribute to sex-biased incidence and outcomes in cancer.

ONLINE COVER Special Issue on Electronic Skin and Computing Hardware for Robotics. In order for robots to be deployed effectively, they must be able to interact with their environment. Yu et al. have developed a printable electronic skin to endow robots with tactile and chemical sensing capabilities to detect physical objects and hazardous materials. The electronic skin can also be affixed to an operator’s arm to detect electromyography signals and to control the movement of a robot. This month’s cover is a photograph of the electronic skin placed on an operator’s arm and also incorporated in the fingers of a robot.

ONLINE COVER This week, Carreras-Sureda et al. discuss the signaling pathways at endoplasmic reticulum (ER)–mitochondria contact sites that regulate the coupling of energy production in mitochondria to protein homeostasis in the ER and how they become dysregulated in disease or pathological contexts. The TEM image shows a mitochondrion (colored in yellow) adjacent to the ER (purple folded structures).

ONLINE COVER Screen Time. This image shows cardiac troponin T (red), myosin binding protein C3 (green), and nuclei (blue) in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Yang et al. used deep learning to screen for cardioprotective agents in hiPSC-CMs deficient in BAG3, a model of dilated cardiomyopathy. Inhibitors of histone deacetylase 6 protected the sarcomeres of hiPSC-CMs and improved cardiac function in cardiomyocyte-specific BAG3 knockout mice and mice with a loss-of-function mutation in BAG3. This phenotypic screening approach could help facilitate drug discovery for cardiomyopathy.